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This site is dedicated to scientific community working on ALS. Our aim is to optimize researchers time and efforts by providing updated, well organized information on novel findings, available resources and research support.
AriSLA - The Foundation for research on ALS - has been set up to make ALS research investments more effective and efficient, to speed up the clinical research impact e and to provide patients with better care, improved conditions and life expectancy. Its aim is to boost Italian excellencies in basic, clinical and technological research. The Foundation founders are Fondazione Cariplo, Fondazione Telethon, Fondazione Vialli and Mauro and AISLA.



New publication on ANS involvement in ALS

Cardiovascular neural regulation is impaired in amyotrophic lateral sclerosis patients. A study by spectral and complexity analysis of cardiovascular oscillations 


Laura Dalla Vecchia1, Beatrice De Maria1, Kalliopi Marinou1,Riccardo Sideri1, Anna Lucini1, Alberto Porta2,3 andGabriele Mora1

1 Istituto Scientifico di Milano, IRCCS Fondazione Salvatore Maugeri, Milano, Italy

2 Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

3 IRCCS Galeazzi Orthopedic Institute, Milan, Italy 

Although the clinical hallmark of amyotrophic lateral sclerosis (ALS) is aprogressive motor weakness, different combinations of autonomic nervoussystem (ANS) dysfunction have been described. No clear correlation betweenANS abnormalities and ALS clinical characteristics has been found so far.We investigated the cardiovascular neural regulation in ALS with a noninvasivemethodology, using spectral and complexity analysis of heart ratevariability (HRV) and systolic arterial pressure (SAP) variability. In allpatients, we found low RR variance and an altered response to orthostasis,witnessed by the indices derived from both spectral and complexity analysisof HRV and SAP variability. Besides, we identified two groups with distinctautonomic profiles at rest, those with higher, and those with lower cardiacsympathetic activity. In both groups the cardiovascular response to tilting wasimpaired. Our study outlined that ANS is invariably impaired in ALS, andpatients can present with different baseline patterns. Our findings suggestimportant pathophysiological, clinical and prognostic insights. The presenceof different autonomic profiles at rest supports the new concept of ALS asa multisystem disorder with phenotypic heterogeneity. Our results are alsorelevant in clinical practice. They can help to improve patients' management,and to identify prognostic factors.

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