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This site is dedicated to scientific community working on ALS. Our aim is to optimize researchers time and efforts by providing updated, well organized information on novel findings, available resources and research support.
AriSLA - The Foundation for research on ALS - has been set up to make ALS research investments more effective and efficient, to speed up the clinical research impact e and to provide patients with better care, improved conditions and life expectancy. Its aim is to boost Italian excellencies in basic, clinical and technological research. The Foundation founders are Fondazione Cariplo, Fondazione Telethon, Fondazione Vialli and Mauro and AISLA.



Induced pluripotent stem cells (iPS): disease models and development of new therapies for ALS

The last seminar organized by AriSLA Foundation has been held on April 14th at AriSLA's headquarter in Viale Ortles 22/4, Milan.


Neurodegenerative diseases, including motor neuron diseases and in particular Amyotrophic Lateral Sclerosis (ALS), do not currently have any effective therapy. The development of new therapeutic approaches is affected by the lack of models that closely replicate the human disease. Recent developments in the field of induced pluripotent stem cells (iPS ) have offered the opportunity to obtain cells, including neurons and glia, that reproduce the specific characteristics of the disease of interest. The objective of this seminar is to provide general information regarding the generation of human iPS cells, and specifically their generation starting from ALS patients' fibroblasts, showing the opportunities and the challenges for the development of in vitro models of the disease. It has been also discussed how the differentiated cells from patient-specific iPS can be used for the development of new therapeutic strategies through the understanding of the molecular mechanisms underlying dysfunction and motor neuron degeneration in ALS .


The seminar was developed through the following themes:

1.     Stem cells and induced pluripotent stem cells: general concepts (generation, differentiation, neurodegenerative diseases models);

2.     Cellular models of ALS based on iPS: motor neuron cultures, co-cultures;

3.     Development of therapies for ALS: drug screening and in vitro molecular models;

4.     Development of therapies for ALS based on iPS: cell transplantation.

The rapporteur:

Dr. Stefania Corti is Assistant Professor in Neurology at the University of Milan. She is currently Neurologist Medical Director at the Neurology UOC, Fondazione IRCCS Ca 'Granda Ospedale Maggiore Policlinico, and head of the Laboratory of Neural Stem Cells, UOC Neurology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan.


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